We examined 47 MS patients, 47 healthy siblings and 50 healthy unrelated individuals with blood and CSF analysis and found that 19 % (9/47) of healthy siblings of clinically definite multiple sclerosis patients had an intrathecal immunological reaction to ¡Ý 2 CSF-enriched OCB, in contrast to 4% (2/50) of the unrelated healthy controls. We termed this condition ¡°MS immunopathic trait¡±. We challenged whether this subgroup with the MS immunopathic trait was really asymptomatic, using a more stringent method, high-pass resolution perimetry (HRP). With this method, siblings as a group did not differ from the healthy controls. We measured CSF neurofilament light protein (NFL), and glial fibrillary acidic protein (GFAp), in MS patients and thei...
The cause of MS is unknown. There is considerable circumstantial evidence that MS is a complex trait...
Multiple sclerosis is a multifactorial autoimmune disease of the central nervous system with three p...
Abnormal intrathecal synthesis of IgG, reflected by cerebrospinal fluid (CSF) oligoclonal IgG bands ...
We found that 19% (9/47) of healthy siblings of patients with clinically definite multiple sclerosis...
A proportion of healthy siblings of multiple sclerosis (MS) patients have an oligodonal immunologica...
Multiple sclerosis (MS) is a disease of the central nervous system characterized by inflammation, de...
Multiple sclerosis (MS) is an inflammatory, demyelinating disease of the central nervous system. Eff...
Multiple sclerosis (MS) is a disease of the central nervous system characterized by inflammation, de...
Multiple sclerosis (MS) is a chronic inflammatory disease characterized by relapsing or progressive ...
Multiple sclerosis (MS) is a chronic inflammatory disease resulting in axonal injury and demyelinat...
Multiple sclerosis (MS) is a chronic disease of the central nervous system, characterized by focal i...
Objective In this observational study, we investigated the impact of genetic factors at the immunogl...
<div><p>Background/Aim</p><p>Multiple sclerosis (MS) is an inflammatory, demyelinating disease of th...
ObjectiveIn this observational study, we investigated the impact of genetic factors at the immunoglo...
Increased intrathecal IgG and oligoclonal bands (OCB) are seminal features of multiple sclerosis (MS...
The cause of MS is unknown. There is considerable circumstantial evidence that MS is a complex trait...
Multiple sclerosis is a multifactorial autoimmune disease of the central nervous system with three p...
Abnormal intrathecal synthesis of IgG, reflected by cerebrospinal fluid (CSF) oligoclonal IgG bands ...
We found that 19% (9/47) of healthy siblings of patients with clinically definite multiple sclerosis...
A proportion of healthy siblings of multiple sclerosis (MS) patients have an oligodonal immunologica...
Multiple sclerosis (MS) is a disease of the central nervous system characterized by inflammation, de...
Multiple sclerosis (MS) is an inflammatory, demyelinating disease of the central nervous system. Eff...
Multiple sclerosis (MS) is a disease of the central nervous system characterized by inflammation, de...
Multiple sclerosis (MS) is a chronic inflammatory disease characterized by relapsing or progressive ...
Multiple sclerosis (MS) is a chronic inflammatory disease resulting in axonal injury and demyelinat...
Multiple sclerosis (MS) is a chronic disease of the central nervous system, characterized by focal i...
Objective In this observational study, we investigated the impact of genetic factors at the immunogl...
<div><p>Background/Aim</p><p>Multiple sclerosis (MS) is an inflammatory, demyelinating disease of th...
ObjectiveIn this observational study, we investigated the impact of genetic factors at the immunoglo...
Increased intrathecal IgG and oligoclonal bands (OCB) are seminal features of multiple sclerosis (MS...
The cause of MS is unknown. There is considerable circumstantial evidence that MS is a complex trait...
Multiple sclerosis is a multifactorial autoimmune disease of the central nervous system with three p...
Abnormal intrathecal synthesis of IgG, reflected by cerebrospinal fluid (CSF) oligoclonal IgG bands ...